The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

In this study the ‘Malaria Box’ chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH of the malaria parasite, Plasmodium falciparum. Fifteen compounds induced an acidification of the parasite cytosol. Two of these did so by in...

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Detalles Bibliográficos
Autores principales: Hapuarachchi, Sanduni V., Cobbold, Simon A., Shafik, Sarah H., Dennis, Adelaide S. M., McConville, Malcolm J., Martin, Rowena E., Kirk, Kiaran, Lehane, Adele M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298231/
https://www.ncbi.nlm.nih.gov/pubmed/28178359
http://dx.doi.org/10.1371/journal.ppat.1006180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298231/
https://www.ncbi.nlm.nih.gov/pubmed/28178359
http://dx.doi.org/10.1371/journal.ppat.1006180

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