Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale

Resistance against all available antimalarial drugs calls for novel compounds that hit unexploited targets in the parasite. Here, we show that the recently discovered Plasmodium falciparum lactate/proton symporter, PfFNT, is a valid druggable target, and describe a new class of fluoroalkyl vinylogou...

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Detalles Bibliográficos
Autores principales: Golldack, André, Henke, Björn, Bergmann, Bärbel, Wiechert, Marie, Erler, Holger, Blancke Soares, Alexandra, Spielmann, Tobias, Beitz, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298233/
https://www.ncbi.nlm.nih.gov/pubmed/28178358
http://dx.doi.org/10.1371/journal.ppat.1006172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298233/
https://www.ncbi.nlm.nih.gov/pubmed/28178358
http://dx.doi.org/10.1371/journal.ppat.1006172

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