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Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale
Resistance against all available antimalarial drugs calls for novel compounds that hit unexploited targets in the parasite. Here, we show that the recently discovered Plasmodium falciparum lactate/proton symporter, PfFNT, is a valid druggable target, and describe a new class of fluoroalkyl vinylogou...
Autores principales: | Golldack, André, Henke, Björn, Bergmann, Bärbel, Wiechert, Marie, Erler, Holger, Blancke Soares, Alexandra, Spielmann, Tobias, Beitz, Eric |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298233/ https://www.ncbi.nlm.nih.gov/pubmed/28178358 http://dx.doi.org/10.1371/journal.ppat.1006172 |
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