Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron

Desferrioxamine (DFO) is a bacterial siderophore with a high affinity for iron, but low cell penetration. As part of our ongoing project focused on DFO-conjugates, we synthesized, purified, characterized and studied new mtDFOs (DFO conjugated to the Mitochondria Penetrating Peptides TAT(49-57), 1A,...

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Detalles Bibliográficos
Autores principales: Alta, Roxana Y. P., Vitorino, Hector A., Goswami, Dibakar, Liria, Cleber W., Wisnovsky, Simon P., Kelley, Shana O., Machini, M. Terêsa, Espósito, Breno P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298241/
https://www.ncbi.nlm.nih.gov/pubmed/28178347
http://dx.doi.org/10.1371/journal.pone.0171729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298241/
https://www.ncbi.nlm.nih.gov/pubmed/28178347
http://dx.doi.org/10.1371/journal.pone.0171729

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