MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding

In this study, we applied molecular dynamics (MD) simulation to analyze the dynamic behavior of the Tat/CycT1/CDK9 tri-molecular complex and revealed the structural changes of P-TEFb upon Tat binding. We found that Tat could deliberately change the local flexibility of CycT1. Although the structural...

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Detalles Bibliográficos
Autores principales: Asamitsu, Kaori, Hirokawa, Takatsugu, Okamoto, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298246/
https://www.ncbi.nlm.nih.gov/pubmed/28178316
http://dx.doi.org/10.1371/journal.pone.0171727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298246/
https://www.ncbi.nlm.nih.gov/pubmed/28178316
http://dx.doi.org/10.1371/journal.pone.0171727

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