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Synthetic lethal mutations in the cyclin A interface of human cytomegalovirus

Generally, the antagonism between host restriction factors and viral countermeasures decides on cellular permissiveness or resistance to virus infection. Human cytomegalovirus (HCMV) has evolved an additional level of self-imposed restriction by the viral tegument protein pp150. Depending on a cycli...

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Detalles Bibliográficos
Autores principales: Weisbach, Henry, Schablowsky, Christoph, Vetter, Barbara, Gruska, Iris, Hagemeier, Christian, Wiebusch, Lüder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298330/
https://www.ncbi.nlm.nih.gov/pubmed/28129404
http://dx.doi.org/10.1371/journal.ppat.1006193