C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta

C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 antagonist, PMX205, decreased amyloid pathology and suppressed cognitive deficits in two Alzheimer's Disease (AD) mouse...

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Detalles Bibliográficos
Autores principales: Hernandez, Michael X., Namiranian, Pouya, Nguyen, Eric, Fonseca, Maria I., Tenner, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298486/
https://www.ncbi.nlm.nih.gov/pubmed/28078911
http://dx.doi.org/10.1177/1759091416687871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298486/
https://www.ncbi.nlm.nih.gov/pubmed/28078911
http://dx.doi.org/10.1177/1759091416687871

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