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NF-κB regulates neuronal ankyrin-G via a negative feedback loop

The axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation experiments in cortical neurons. Overexpression o...

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Detalles Bibliográficos
Autores principales: König, Hans-Georg, Schwamborn, Robert, Andresen, Silke, Kinsella, Sinéad, Watters, Orla, Fenner, Beau, Prehn, Jochen H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299403/
https://www.ncbi.nlm.nih.gov/pubmed/28181483
http://dx.doi.org/10.1038/srep42006