Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates

A strategy for the preparation of homogeneous antibody–drug conjugates (ADCs) containing multiple payloads has been developed. This approach utilizes sequential unmasking of cysteine residues with orthogonal protection to enable site‐specific conjugation of each drug. In addition, because the approa...

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Detalles Bibliográficos
Autores principales: Levengood, Matthew R., Zhang, Xinqun, Hunter, Joshua H., Emmerton, Kim K., Miyamoto, Jamie B., Lewis, Timothy S., Senter, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299463/
https://www.ncbi.nlm.nih.gov/pubmed/27966822
http://dx.doi.org/10.1002/anie.201608292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299463/
https://www.ncbi.nlm.nih.gov/pubmed/27966822
http://dx.doi.org/10.1002/anie.201608292

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