One‐stage individual participant data meta‐analysis models: estimation of treatment‐covariate interactions must avoid ecological bias by separating out within‐trial and across‐trial information

Stratified medicine utilizes individual‐level covariates that are associated with a differential treatment effect, also known as treatment‐covariate interactions. When multiple trials are available, meta‐analysis is used to help detect true treatment‐covariate interactions by combining their data. M...

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Detalles Bibliográficos
Autores principales: Hua, Hairui, Burke, Danielle L., Crowther, Michael J., Ensor, Joie, Tudur Smith, Catrin, Riley, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299543/
https://www.ncbi.nlm.nih.gov/pubmed/27910122
http://dx.doi.org/10.1002/sim.7171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299543/
https://www.ncbi.nlm.nih.gov/pubmed/27910122
http://dx.doi.org/10.1002/sim.7171

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