Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Multidrug resistance (MDR) attenuates the chemotherapy efficacy and increases the probability of cancer recurrence. The accelerated drug efflux mediated by ATP-binding cassette (ABC) transporters is one of the major MDR mechanisms. This study investigated if TTT-28, a newly synthesized thiazole-vali...

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Detalles Bibliográficos
Autores principales: Wang, Yi-Jun, Patel, Bhargav A., Anreddy, Nagaraju, Zhang, Yun-Kai, Zhang, Guan-Nan, Alqahtani, Saeed, Singh, Satyakam, Shukla, Suneet, Kaddoumi, Amal, Ambudkar, Suresh V., Talele, Tanaji T., Chen, Zhe-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299601/
https://www.ncbi.nlm.nih.gov/pubmed/28181548
http://dx.doi.org/10.1038/srep42106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299601/
https://www.ncbi.nlm.nih.gov/pubmed/28181548
http://dx.doi.org/10.1038/srep42106

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