Cyclic AMP reverses the effects of aging on pacemaker activity and I(f) in sinoatrial node myocytes

Aerobic capacity decreases with age, in part because of an age-dependent decline in maximum heart rate (mHR) and a reduction in the intrinsic pacemaker activity of the sinoatrial node of the heart. Isolated sinoatrial node myocytes (SAMs) from aged mice have slower spontaneous action potential (AP)...

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Detalles Bibliográficos
Autores principales: Sharpe, Emily J., Larson, Eric D., Proenza, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299620/
https://www.ncbi.nlm.nih.gov/pubmed/28057842
http://dx.doi.org/10.1085/jgp.201611674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299620/
https://www.ncbi.nlm.nih.gov/pubmed/28057842
http://dx.doi.org/10.1085/jgp.201611674

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