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The HOOK region of voltage-gated Ca(2+) channel β subunits senses and transmits PIP(2) signals to the gate
The β subunit of voltage-gated Ca(2+) (Ca(V)) channels plays an important role in regulating gating of the α1 pore-forming subunit and its regulation by phosphatidylinositol 4,5-bisphosphate (PIP(2)). Subcellular localization of the Ca(V) β subunit is critical for this effect; N-terminal–dependent m...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299622/ https://www.ncbi.nlm.nih.gov/pubmed/28087621 http://dx.doi.org/10.1085/jgp.201611677 |