The intrinsically liganded cyclic nucleotide–binding homology domain promotes KCNH channel activation

Channels in the ether-à-go-go or KCNH family of potassium channels are characterized by a conserved, C-terminal domain with homology to cyclic nucleotide–binding homology domains (CNBhDs). Instead of cyclic nucleotides, two amino acid residues, Y699 and L701, occupy the binding pocket, forming an “i...

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Detalles Bibliográficos
Autores principales: Zhao, Yaxian, Goldschen-Ohm, Marcel P., Morais-Cabral, João H., Chanda, Baron, Robertson, Gail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299623/
https://www.ncbi.nlm.nih.gov/pubmed/28122815
http://dx.doi.org/10.1085/jgp.201611701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299623/
https://www.ncbi.nlm.nih.gov/pubmed/28122815
http://dx.doi.org/10.1085/jgp.201611701

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