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Calmodulin limits pathogenic Na(+) channel persistent current
Increased “persistent” current, caused by delayed inactivation, through voltage-gated Na(+) (Na(V)) channels leads to cardiac arrhythmias or epilepsy. The underlying molecular contributors to these inactivation defects are poorly understood. Here, we show that calmodulin (CaM) binding to multiple si...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299624/ https://www.ncbi.nlm.nih.gov/pubmed/28087622 http://dx.doi.org/10.1085/jgp.201611721 |