Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die

The mammalian target of rapamycin (mTOR) is a key regulator of cell growth, autophagy, translation, and survival. Dysregulation of mTOR signaling is associated with cancer, diabetes, and autism. However, a role for mTOR signaling in neuronal death is not well delineated. Here we show that global isc...

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Detalles Bibliográficos
Autores principales: Hwang, Jee-Yeon, Gertner, Michael, Pontarelli, Fabrizio, Court-Vazquez, Brenda, Bennett, Michael Vander Laan, Ofengeim, Dimitry, Zukin, Ruth Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299717/
https://www.ncbi.nlm.nih.gov/pubmed/27935582
http://dx.doi.org/10.1038/cdd.2016.140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299717/
https://www.ncbi.nlm.nih.gov/pubmed/27935582
http://dx.doi.org/10.1038/cdd.2016.140

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