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Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation

BACKGROUND: We previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increases the turnover of plasma lysophosphatidate and decreases its concentration. E...

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Detalles Bibliográficos
Autores principales: Tang, Xiaoyun, Wang, Xianyan, Zhao, Yuan Y., Curtis, Jonathan M., Brindley, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299726/
https://www.ncbi.nlm.nih.gov/pubmed/28178994
http://dx.doi.org/10.1186/s12943-017-0607-x