Cargando…
Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain...
Autores principales: | Bartha, István, McLaren, Paul J., Brumme, Chanson, Harrigan, Richard, Telenti, Amalio, Fellay, Jacques |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300119/ https://www.ncbi.nlm.nih.gov/pubmed/28182649 http://dx.doi.org/10.1371/journal.pcbi.1005339 |
Ejemplares similares
-
GuavaH: a compendium of host genomic data in HIV biology and disease
por: Bartha, István, et al.
Publicado: (2014) -
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
por: Bartha, István, et al.
Publicado: (2013) -
Analysis of Stop-Gain and Frameshift Variants in Human Innate Immunity Genes
por: Rausell, Antonio, et al.
Publicado: (2014) -
Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints
por: Snoeck, Joke, et al.
Publicado: (2011) -
The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome
por: Bartha, István, et al.
Publicado: (2015)