Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function

BACKGROUND: Accumulating evidence suggests that hypoxic areas in the bone marrow are crucial for maintenance of hematopoietic stem cells (HSCs) by supporting a quiescent state of cell cycle and regulating the transplantation capacity of long-term (LT)-HSCs. In addition, HSCs seem to express a metabo...

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Detalles Bibliográficos
Autores principales: Halvarsson, Camilla, Eliasson, Pernilla, Jönsson, Jan-Ingvar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300157/
https://www.ncbi.nlm.nih.gov/pubmed/28182733
http://dx.doi.org/10.1371/journal.pone.0171714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300157/
https://www.ncbi.nlm.nih.gov/pubmed/28182733
http://dx.doi.org/10.1371/journal.pone.0171714

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