Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming

Global DNA demethylation is an integral part of reprogramming processes in vivo and in vitro, but whether it occurs in the derivation of induced pluripotent stem cells (iPSCs) is not known. Here, we show that iPSC reprogramming involves both global and targeted demethylation, which are separable mec...

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Detalles Bibliográficos
Autores principales: Milagre, Inês, Stubbs, Thomas M., King, Michelle R., Spindel, Julia, Santos, Fátima, Krueger, Felix, Bachman, Martin, Segonds-Pichon, Anne, Balasubramanian, Shankar, Andrews, Simon R., Dean, Wendy, Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300890/
https://www.ncbi.nlm.nih.gov/pubmed/28147265
http://dx.doi.org/10.1016/j.celrep.2017.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300890/
https://www.ncbi.nlm.nih.gov/pubmed/28147265
http://dx.doi.org/10.1016/j.celrep.2017.01.008

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