Dopamine-Induced Changes in Gα(olf) Protein Levels in Striatonigral and Striatopallidal Medium Spiny Neurons Underlie the Genesis of l-DOPA-Induced Dyskinesia in Parkinsonian Mice

The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson’s disease (PD). LID has a close link with deregulation of striatal dopamine/cAMP signaling, which is integrated by me...

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Detalles Bibliográficos
Autores principales: Morigaki, Ryoma, Okita, Shinya, Goto, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300978/
https://www.ncbi.nlm.nih.gov/pubmed/28239340
http://dx.doi.org/10.3389/fncel.2017.00026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300978/
https://www.ncbi.nlm.nih.gov/pubmed/28239340
http://dx.doi.org/10.3389/fncel.2017.00026

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