Cargando…

Dopamine-Induced Changes in Gα(olf) Protein Levels in Striatonigral and Striatopallidal Medium Spiny Neurons Underlie the Genesis of l-DOPA-Induced Dyskinesia in Parkinsonian Mice

The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson’s disease (PD). LID has a close link with deregulation of striatal dopamine/cAMP signaling, which is integrated by me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morigaki, Ryoma, Okita, Shinya, Goto, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300978/ https://www.ncbi.nlm.nih.gov/pubmed/28239340 http://dx.doi.org/10.3389/fncel.2017.00026

Ejemplares similares

What is the Degree of Segregation between Striatonigral and Striatopallidal Projections?
por: Bertran-Gonzalez, Jesus, et al.
Publicado: (2010)

Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways
por: Bakhurin, Konstantin I, et al.
Publicado: (2020)

Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice
por: Shi, Ziqing, et al.
Publicado: (2020)

Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions
por: Smith, Alexander C. W., et al.
Publicado: (2021)

Striatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats
por: Fieblinger, T., et al.
Publicado: (2018)

7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate
por: Herrero, M. T., et al.
Publicado: (2023)

L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission
por: Feyder, Michael, et al.
Publicado: (2011)

D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
por: Florio, Ermanno, et al.
Publicado: (2022)

Spontaneous locomotor activity and L-DOPA-induced dyskinesia are not linked in 6-OHDA parkinsonian rats
por: Sgroi, Stefania, et al.
Publicado: (2014)

L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum
por: Porras, Gregory, et al.
Publicado: (2014)

The locus coeruleus Is Directly Implicated in L-DOPA-Induced Dyskinesia in Parkinsonian Rats: An Electrophysiological and Behavioural Study
por: Miguelez, Cristina, et al.
Publicado: (2011)

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
por: Martín-Ibáñez, Raquel, et al.
Publicado: (2017)

The Vasomotor Response to Dopamine Is Altered in the Rat Model of l‐dopa‐Induced Dyskinesia
por: Booth, Samuel, et al.
Publicado: (2020)

IRC-082451, a Novel Multitargeting Molecule, Reduces L-DOPA-Induced Dyskinesias in MPTP Parkinsonian Primates
por: Aron Badin, Romina, et al.
Publicado: (2013)

Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline
por: Nascimento, G.C., et al.
Publicado: (2023)

L-dopa response pattern in a rat model of mild striatonigral degeneration
por: Kaindlstorfer, Christine, et al.
Publicado: (2019)

Polymorphisms of Dopamine Receptor Genes and Risk of L-Dopa–Induced Dyskinesia in Parkinson’s Disease
por: Comi, Cristoforo, et al.
Publicado: (2017)

Dopamine D3 Receptor Plasticity in Parkinson’s Disease and L-DOPA-Induced Dyskinesia
por: Lanza, Kathryn, et al.
Publicado: (2021)

Correction: IRC-082451, a Novel Multitargeting Molecule, Reduces L-DOPA-Induced Dyskinesias in MPTP Parkinsonian Primates
por: Aron Badin, Romina, et al.
Publicado: (2013)

Opioid system in L-DOPA-induced dyskinesia
por: Pan, Jing, et al.
Publicado: (2017)

Striatal Gα(olf)/cAMP Signal-Dependent Mechanism to Generate Levodopa-Induced Dyskinesia in Parkinson’s Disease
por: Goto, Satoshi
Publicado: (2017)

Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys
por: Morissette, Marc, et al.
Publicado: (2022)

The Dopamine D5 receptor contributes to activation of cholinergic interneurons during L-DOPA induced dyskinesia
por: Castello, Julia, et al.
Publicado: (2020)

An Improved BAC Transgenic Fluorescent Reporter Line for Sensitive and Specific Identification of Striatonigral Medium Spiny Neurons
por: Ade, Kristen K., et al.
Publicado: (2011)

Maladaptive Synaptic Plasticity in L-DOPA-Induced Dyskinesia
por: Wang, Qiang, et al.
Publicado: (2016)

On the neuronal circuitry mediating l-DOPA-induced dyskinesia
por: Cenci, M. Angela, et al.
Publicado: (2018)

Predictors of Levo-dopa induced Dyskinesias in Parkinson's Disease
por: Athulya, RT, et al.
Publicado: (2020)

Circuit Mechanisms of L-DOPA-Induced Dyskinesia (LID)
por: Yang, Kai, et al.
Publicado: (2021)

Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists
por: Pogorelov, Vladimir M., et al.
Publicado: (2023)

Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease
por: Sahin, Gurdal, et al.
Publicado: (2014)

Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia
por: Ghiglieri, Veronica, et al.
Publicado: (2012)

Pathophysiological Mechanisms and Experimental Pharmacotherapy for L-Dopa-Induced Dyskinesia
por: Fabbrini, Andrea, et al.
Publicado: (2021)

GABA(A) Receptor β3 Subunit Expression Regulates Tonic Current in Developing Striatopallidal Medium Spiny Neurons
por: Janssen, Megan J., et al.
Publicado: (2011)

mGlu5, Dopamine D(2) and Adenosine A(2A) Receptors in L-DOPA-induced Dyskinesias
por: Morin, Nicolas, et al.
Publicado: (2016)

Publisher Correction: The Dopamine D5 receptor contributes to activation of cholinergic interneurons during L-DOPA induced dyskinesia
por: Castello, Julia, et al.
Publicado: (2020)

Freezing of saccades in dopa-responsive parkinsonian syndrome
por: Likitgorn, Techawit, et al.
Publicado: (2021)

Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons
por: Podleśny-Drabiniok, Anna, et al.
Publicado: (2017)

Striatal Plasticity in L-DOPA- and Graft-Induced Dyskinesia; The Common Link?
por: Rylander Ottosson, Daniella, et al.
Publicado: (2016)

Inhaling xenon ameliorates l‐dopa‐induced dyskinesia in experimental parkinsonism
por: Baufreton, Jérôme, et al.
Publicado: (2018)

Involvement of the bed nucleus of the stria terminalis in L-Dopa induced dyskinesia
por: Bastide, Matthieu F., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_95q92gl0gbmkmn0a1t1tei9qef