Gene Transfer of Prolyl Hydroxylase Domain 2 Inhibits Hypoxia-inducible Angiogenesis in a Model of Choroidal Neovascularization

Cellular responses to hypoxia are mediated by the hypoxia-inducible factors (HIF). In normoxia, HIF-α proteins are regulated by a family of dioxygenases, through prolyl and asparagyl hydroxylation, culminating in proteasomal degradation and transcriptional inactivation. In hypoxia, the dioxygenases...

Descripción completa

Detalles Bibliográficos
Autores principales: Takei, Anna, Ekström, Malena, Mammadzada, Parviz, Aronsson, Monica, Yu, Ma, Kvanta, Anders, André, Helder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301234/
https://www.ncbi.nlm.nih.gov/pubmed/28186209
http://dx.doi.org/10.1038/srep42546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301234/
https://www.ncbi.nlm.nih.gov/pubmed/28186209
http://dx.doi.org/10.1038/srep42546

Ejemplares similares