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A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer’s Disease

The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer’s disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), we compared the effect of APOE and amyloid-β (Aβ) on baseline hippocampal volum...

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Detalles Bibliográficos
Autores principales: Khan, Wasim, Giampietro, Vincent, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Büchel, Christian, Conrod, Patricia, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Anreas, Ittermann, Bernd, Lemaître, Hervé, Nees, Frauke, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Smolka, Michael N., Ströhle, Andreas, Gallinat, Jeurgen, Vellas, Bruno, Soininen, Hilkka, Kloszewska, Iwona, Tsolaki, Magda, Mecocci, Patrizia, Spenger, Christian, Villemagne, Victor L., Masters, Colin L., Muehlboeck, J-Sebastian, Bäckman, Lars, Fratiglioni, Laura, Kalpouzos, Grégoria, Wahlund, Lars-Olof, Schumann, Gunther, Lovestone, Simon, Williams, Steven C.R., Westman, Eric, Simmons, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302035/
https://www.ncbi.nlm.nih.gov/pubmed/28157104
http://dx.doi.org/10.3233/JAD-161097