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Molecular mechanism for the regulation of yeast separase by securin
Separase has a critical role in dissolving the cohesion among sister chromatids during chromosome segregation (1–7). Separase is over-expressed in human tumors, making it a potential target for drug discovery (8). The protease activity of separase is strictly regulated by the inhibitor securin, whic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302053/ https://www.ncbi.nlm.nih.gov/pubmed/28146474 http://dx.doi.org/10.1038/nature21061 |