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Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis

Phosphopantetheinyl transferases (PPTases) are key elements in the modular syntheses performed by multienzyme systems such as polyketide synthases. PPTases transfer phosphopantetheine derivatives from Coenzyme A to carrier proteins (CPs), thus orchestrating substrate supply. We describe an efficient...

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Detalles Bibliográficos
Autores principales: Jung, James, Bashiri, Ghader, Johnston, Jodie M., Baker, Edward N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302061/
https://www.ncbi.nlm.nih.gov/pubmed/28203522
http://dx.doi.org/10.1002/2211-5463.12140