Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3

Myeloproliferative neoplasms (MPN), which overproduce blood cells in the bone marrow, have recently been linked with a genetically determined decrease in expression of the MYB transcription factor. Here, we use a mouse MYB knockdown model with an MPN-like phenotype to show how lower levels of MYB le...

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Detalles Bibliográficos
Autores principales: Clarke, Mary, Volpe, Giacomo, Sheriff, Lozan, Walton, David, Ward, Carl, Wei, Wenbin, Dumon, Stephanie, García, Paloma, Frampton, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302168/
https://www.ncbi.nlm.nih.gov/pubmed/27748374
http://dx.doi.org/10.1038/leu.2016.289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302168/
https://www.ncbi.nlm.nih.gov/pubmed/27748374
http://dx.doi.org/10.1038/leu.2016.289

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