Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain

Drugs able to treat both nociceptive and neuropathic pain effectively without major side effects are lacking. We developed a bifunctional peptide-based hybrid (KGNOP1) that structurally combines a mu-opioid receptor agonist (KGOP1) with antinociceptive activity and a weak nociceptin receptor antagon...

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Detalles Bibliográficos
Autores principales: Lagard, Camille, Chevillard, Lucie, Guillemyn, Karel, Risède, Patricia, Laplanche, Jean-Louis, Spetea, Mariana, Ballet, Steven, Mégarbane, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302413/
https://www.ncbi.nlm.nih.gov/pubmed/28135212
http://dx.doi.org/10.1097/j.pain.0000000000000790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302413/
https://www.ncbi.nlm.nih.gov/pubmed/28135212
http://dx.doi.org/10.1097/j.pain.0000000000000790

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