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Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain

Drugs able to treat both nociceptive and neuropathic pain effectively without major side effects are lacking. We developed a bifunctional peptide-based hybrid (KGNOP1) that structurally combines a mu-opioid receptor agonist (KGOP1) with antinociceptive activity and a weak nociceptin receptor antagon...

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Detalles Bibliográficos
Autores principales:	Lagard, Camille, Chevillard, Lucie, Guillemyn, Karel, Risède, Patricia, Laplanche, Jean-Louis, Spetea, Mariana, Ballet, Steven, Mégarbane, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302413/ https://www.ncbi.nlm.nih.gov/pubmed/28135212 http://dx.doi.org/10.1097/j.pain.0000000000000790

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