Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hypercontractility, and therapies are aimed toward controlling the hyperactive physiology. Mutations in the β-cardiac myosin comprise...

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Detalles Bibliográficos
Autores principales: Kawana, Masataka, Sarkar, Saswata S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302870/
https://www.ncbi.nlm.nih.gov/pubmed/28246639
http://dx.doi.org/10.1126/sciadv.1601959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302870/
https://www.ncbi.nlm.nih.gov/pubmed/28246639
http://dx.doi.org/10.1126/sciadv.1601959

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