Cargando…

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hypercontractility, and therapies are aimed toward controlling the hyperactive physiology. Mutations in the β-cardiac myosin comprise...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kawana, Masataka, Sarkar, Saswata S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302870/ https://www.ncbi.nlm.nih.gov/pubmed/28246639 http://dx.doi.org/10.1126/sciadv.1601959

Ejemplares similares

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
por: Adhikari, Arjun S., et al.
Publicado: (2019)

Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies
por: Kawana, Masataka, et al.
Publicado: (2022)

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
por: Trivedi, Darshan V., et al.
Publicado: (2017)

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function
por: Nag, Suman, et al.
Publicado: (2015)

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
por: Sarkar, Saswata S., et al.
Publicado: (2020)

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
por: Morck, Makenna M, et al.
Publicado: (2022)

Controlling load-dependent kinetics of β-cardiac myosin at the single molecule level
por: Liu, Chao, et al.
Publicado: (2018)

Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin
por: Sommese, Ruth F., et al.
Publicado: (2013)

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
por: Vander Roest, Alison Schroer, et al.
Publicado: (2021)

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector
por: Aksel, Tural, et al.
Publicado: (2015)

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules
por: Sung, Jongmin, et al.
Publicado: (2015)

The Hypertrophic Cardiomyopathy Myosin Mutation R453C Alters ATP Binding and Hydrolysis of Human Cardiac β-Myosin
por: Bloemink, Marieke, et al.
Publicado: (2014)

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin
por: Pan, Stephen, et al.
Publicado: (2015)

Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy
por: Tripathi, Snigdha, et al.
Publicado: (2011)

Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy
por: Hsieh, Jeanne, et al.
Publicado: (2022)

Cryo-EM structure of the folded-back state of human β-cardiac myosin(*)
por: Grinzato, Alessandro, et al.
Publicado: (2023)

Cryo-EM structure of the folded-back state of human β-cardiac myosin
por: Grinzato, Alessandro, et al.
Publicado: (2023)

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
por: Spudich, James A.
Publicado: (2019)

Mutations in myosin S2 alter cardiac myosin-binding protein-C interaction in hypertrophic cardiomyopathy in a phosphorylation-dependent manner
por: Singh, Rohit R., et al.
Publicado: (2021)

The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy
por: Jacques, Adam M., et al.
Publicado: (2008)

Prevalence of cardiac myosin-binding protein C3 mutations in Maine Coon cats with hypertrophic cardiomyopathy
por: Sukumolanan, Pratch, et al.
Publicado: (2022)

Moderating the Myosin Motor to Treat Hypertrophic Cardiomyopathy
por: Papp, Zoltán
Publicado: (2022)

Unexpectedly Low Mutation Rates in Beta-Myosin Heavy Chain and Cardiac Myosin Binding Protein Genes in Italian Patients With Hypertrophic Cardiomyopathy
por: Roncarati, Roberta, et al.
Publicado: (2011)

Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C
por: Stern, Joshua A., et al.
Publicado: (2023)

The R403Q Myosin Mutation Implicated in Familial Hypertrophic Cardiomyopathy Causes Disorder at the Actomyosin Interface
por: Volkmann, Niels, et al.
Publicado: (2007)

Myosins and MyomiR Network in Patients with Obstructive Hypertrophic Cardiomyopathy
por: Foglieni, Chiara, et al.
Publicado: (2022)

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
por: Robert-Paganin, Julien, et al.
Publicado: (2018)

Mutation Analysis of Three Exons of Myosin-Binding Protein C3 in Patients with Hypertrophic Cardiomyopathy
por: Mobasheri, Maryam Beigom, et al.
Publicado: (2016)

Hypertrophic cardiomyopathy in myosin-binding protein C (MYBPC3) Icelandic founder mutation carriers
por: Adalsteinsdottir, Berglind, et al.
Publicado: (2020)

Classifying Cardiac Actin Mutations Associated With Hypertrophic Cardiomyopathy
por: Despond, Evan A., et al.
Publicado: (2018)

Cardiac Myosin Inhibitors as a Novel Treatment Option for Obstructive Hypertrophic Cardiomyopathy: Addressing the Core of the Matter
por: Masri, Ahmad, et al.
Publicado: (2022)

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2018)

Mavacamten: a first-in-class myosin inhibitor for obstructive hypertrophic cardiomyopathy
por: Braunwald, Eugene, et al.
Publicado: (2023)

Screening mutations in myosin binding protein C3 gene in a cohort of patients with Hypertrophic Cardiomyopathy
por: Rodríguez-García, María Isabel, et al.
Publicado: (2010)

Dictyostelium Myosin Bipolar Thick Filament Formation: Importance of Charge and Specific Domains of the Myosin Rod
por: Hostetter, Daniel, et al.
Publicado: (2004)

A Novel Myosin Essential Light Chain Mutation Causes Hypertrophic Cardiomyopathy with Late Onset and Low Expressivity
por: Andersen, Paal Skytt, et al.
Publicado: (2012)

Getting inside the engine - myosin modulation in hypertrophic cardiomyopathy and systolic heart failure
por: Daniels, Matthew J, et al.
Publicado: (2021)

Correction: Dictyostelium Myosin Bipolar Thick Filament Formation: Importance of Charge and Specific Domains of the Myosin Rod
por: Hostetter, Daniel, et al.
Publicado: (2005)

The Influence of Angiotensin Converting Enzyme and Angiotensinogen Gene Polymorphisms on Hypertrophic Cardiomyopathy
por: Luo, Rong, et al.
Publicado: (2013)

Homologous mutations in [Formula: see text] , embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
por: Liu, Chao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pvfe24ggkp9gnm3v8d1bcr2qoo