Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low-affinity tense (T) and multiple high-affinity...

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Detalles Bibliográficos
Autores principales: Kalas, Vasilios, Pinkner, Jerome S., Hannan, Thomas J., Hibbing, Michael E., Dodson, Karen W., Holehouse, Alex S., Zhang, Hao, Tolia, Niraj H., Gross, Michael L., Pappu, Rohit V., Janetka, James, Hultgren, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302871/
https://www.ncbi.nlm.nih.gov/pubmed/28246638
http://dx.doi.org/10.1126/sciadv.1601944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302871/
https://www.ncbi.nlm.nih.gov/pubmed/28246638
http://dx.doi.org/10.1126/sciadv.1601944

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