Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice

BACKGROUND: In this study, we investigated the direct effect of C5a overexpression on atherosclerosis. METHODS AND RESULTS: A recombinant adenovirus expressing mouse C5a (Ad-C5a) was constructed and injected intravenously into ApoE(−/−) mice. After 12 weeks of a high-fat diet, Ad-C5a injection produ...

Descripción completa

Detalles Bibliográficos
Autores principales: An, Guipeng, Li, Bo, Liu, Xiaoman, Zhang, Mingxiang, Gao, Fei, Zhao, Yuxia, An, Fengshuang, Zhang, Yun, Zhang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302896/
https://www.ncbi.nlm.nih.gov/pubmed/27517153
http://dx.doi.org/10.18632/oncotarget.11180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302896/
https://www.ncbi.nlm.nih.gov/pubmed/27517153
http://dx.doi.org/10.18632/oncotarget.11180

Ejemplares similares