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Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice

BACKGROUND: In this study, we investigated the direct effect of C5a overexpression on atherosclerosis. METHODS AND RESULTS: A recombinant adenovirus expressing mouse C5a (Ad-C5a) was constructed and injected intravenously into ApoE(−/−) mice. After 12 weeks of a high-fat diet, Ad-C5a injection produ...

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Detalles Bibliográficos
Autores principales:	An, Guipeng, Li, Bo, Liu, Xiaoman, Zhang, Mingxiang, Gao, Fei, Zhao, Yuxia, An, Fengshuang, Zhang, Yun, Zhang, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302896/ https://www.ncbi.nlm.nih.gov/pubmed/27517153 http://dx.doi.org/10.18632/oncotarget.11180

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