HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance

Decreased expression of NKG2D ligands on HBV-infected human hepatoma cells impairs NK cells lysis. However, which components of HBV exert this effect and the precise mechanisms need to be further investigated. In the present study, we observed that the HBx and HBc genes significantly down-regulated...

Descripción completa

Detalles Bibliográficos
Autores principales: Guan, Yun, Li, Weiqun, Hou, Zhaohua, Han, Qiuju, Lan, Peixiang, Zhang, Jian, Tian, Zhigang, Zhang, Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302899/
https://www.ncbi.nlm.nih.gov/pubmed/27528231
http://dx.doi.org/10.18632/oncotarget.11271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302899/
https://www.ncbi.nlm.nih.gov/pubmed/27528231
http://dx.doi.org/10.18632/oncotarget.11271

Ejemplares similares