Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma

Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. Here, we studied the effects of phenformin, a mitochondrial complex I inhibitor and more potent chemical analog of the diabetes drug metformin on the inhibition of cell growth and induction of apoptosis of glioma stem...

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Detalles Bibliográficos
Autores principales: Jiang, Wei, Finniss, Susan, Cazacu, Simona, Xiang, Cunli, Brodie, Ziv, Mikkelsen, Tom, Poisson, Laila, Shackelford, David B., Brodie, Chaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302927/
https://www.ncbi.nlm.nih.gov/pubmed/27486821
http://dx.doi.org/10.18632/oncotarget.10919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302927/
https://www.ncbi.nlm.nih.gov/pubmed/27486821
http://dx.doi.org/10.18632/oncotarget.10919

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