Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling

BACKGROUND: Cell-based gene therapy has become a subject of interest for the treatment of pulmonary arterial hypertension (PAH), a devastating disease characterized by pulmonary artery smooth muscle cell (PASMC) hyperplasia. Mesenchymal stem cells (MSCs) have been recently acknowledged as a potentia...

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Detalles Bibliográficos
Autores principales: Cheng, Gesheng, Wang, Xingye, Li, Yongxin, He, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303212/
https://www.ncbi.nlm.nih.gov/pubmed/28187784
http://dx.doi.org/10.1186/s13287-017-0480-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303212/
https://www.ncbi.nlm.nih.gov/pubmed/28187784
http://dx.doi.org/10.1186/s13287-017-0480-y

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