AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells

The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA. AlkB homolog...

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Detalles Bibliográficos
Autores principales: Ueda, Yuko, Ooshio, Ikumi, Fusamae, Yasuyuki, Kitae, Kaori, Kawaguchi, Megumi, Jingushi, Kentaro, Hase, Hiroaki, Harada, Kazuo, Hirata, Kazumasa, Tsujikawa, Kazutake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304225/
https://www.ncbi.nlm.nih.gov/pubmed/28205560
http://dx.doi.org/10.1038/srep42271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304225/
https://www.ncbi.nlm.nih.gov/pubmed/28205560
http://dx.doi.org/10.1038/srep42271

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