Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells

Detachment of cells from the primary tumour precedes metastatic progression by facilitating cell release into the tissue. Solid tumours exhibit altered pH homeostasis with extracellular acidification. In human melanoma, the Na(+)/H(+) exchanger NHE1 is an important modifier of the tumour nanoenviron...

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Detalles Bibliográficos
Autores principales: Hofschröer, Verena, Koch, Alexander, Ludwig, Florian Timo, Friedl, Peter, Oberleithner, Hans, Stock, Christian, Schwab, Albrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304230/
https://www.ncbi.nlm.nih.gov/pubmed/28205573
http://dx.doi.org/10.1038/srep42369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304230/
https://www.ncbi.nlm.nih.gov/pubmed/28205573
http://dx.doi.org/10.1038/srep42369

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