Cargando…

Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors

Efficient differentiation of human pluripotent stem cells (hPSCs) into neurons is paramount for disease modeling, drug screening, and cell transplantation therapy in regenerative medicine. In this manuscript, we report the capability of five transcription factors (TFs) toward this aim: NEUROG1, NEUR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goparaju, Sravan Kumar, Kohda, Kazuhisa, Ibata, Keiji, Soma, Atsumi, Nakatake, Yukhi, Akiyama, Tomohiko, Wakabayashi, Shunichi, Matsushita, Misako, Sakota, Miki, Kimura, Hiromi, Yuzaki, Michisuke, Ko, Shigeru B. H., Ko, Minoru S. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304326/ https://www.ncbi.nlm.nih.gov/pubmed/28205555 http://dx.doi.org/10.1038/srep42367

Ejemplares similares

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells
por: Hirayama, Masatoshi, et al.
Publicado: (2017)

Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells
por: Akiyama, Tomohiko, et al.
Publicado: (2016)

Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells
por: Akiyama, Tomohiko, et al.
Publicado: (2017)

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors
por: Ida, Hideomi, et al.
Publicado: (2018)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors
por: Hiratsuka, Ken, et al.
Publicado: (2019)

Unlocking the secrets of the δ2 glutamate receptor: A gatekeeper for synaptic plasticity in the cerebellum
por: Kohda, Kazuhisa, et al.
Publicado: (2013)

Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors
por: Zhou, Zhi, et al.
Publicado: (2014)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing
por: Akiyama, Tomohiko, et al.
Publicado: (2018)

Efficient Derivation of Multipotent Neural Stem/Progenitor Cells from Non-Human Primate Embryonic Stem Cells
por: Shimada, Hiroko, et al.
Publicado: (2012)

Reevaluation of the role of parallel fiber synapses in delay eyeblink conditioning in mice using Cbln1 as a tool
por: Emi, Kyoichi, et al.
Publicado: (2013)

Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes
por: Imaizumi, Kent, et al.
Publicado: (2015)

Resilience to capsaicin-induced mitochondrial damage in trigeminal ganglion neurons
por: Shibata, Mamoru, et al.
Publicado: (2020)

Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis
por: Ishiguro, Kei-ichiro, et al.
Publicado: (2016)

Functional interactions between transient receptor potential M8 and transient receptor potential V1 in the trigeminal system: Relevance to migraine pathophysiology
por: Kayama, Yohei, et al.
Publicado: (2017)

Chemical labelling for visualizing native AMPA receptors in live neurons
por: Wakayama, Sho, et al.
Publicado: (2017)

Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos
por: Ishiguro, Kei-ichiro, et al.
Publicado: (2016)

Subunit-dependent and subunit-independent rules of AMPA receptor trafficking during chemical long-term depression in hippocampal neurons
por: Matsuda, Shinji, et al.
Publicado: (2021)

PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo
por: Matsuda, Shinji, et al.
Publicado: (2019)

C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity
por: Aimi, Takahiro, et al.
Publicado: (2023)

Involvement of GluD2 in Fear-Conditioned Bradycardia in Mice
por: Kotajima-Murakami, Hiroko, et al.
Publicado: (2016)

Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice
por: Takeuchi, Eri, et al.
Publicado: (2018)

A Computational Model for the AMPA Receptor Phosphorylation Master Switch Regulating Cerebellar Long-Term Depression
por: Gallimore, Andrew R., et al.
Publicado: (2016)

Characteristics of Gait Ataxia in δ2 Glutamate Receptor Mutant Mice, ho15J
por: Takeuchi, Eri, et al.
Publicado: (2012)

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis
por: Sato, Takashi, et al.
Publicado: (2014)

Caveolin-1 Promotes Early Neuronal Maturation via Caveolae-Independent Trafficking of N-Cadherin and L1
por: Shikanai, Mima, et al.
Publicado: (2018)

In vivo Two-Photon Imaging of Anesthesia-Specific Alterations in Microglial Surveillance and Photodamage-Directed Motility in Mouse Cortex
por: Sun, Weilun, et al.
Publicado: (2019)

Formation and Removal of DNA Adducts in the Liver of Rats Chronically Fed the Food‐borne Carcinogen, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline
por: Hirose, Misako, et al.
Publicado: (1995)

Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent
por: Thimaradka, Vikram, et al.
Publicado: (2021)

Gene array analysis of neural crest cells identifies transcription factors necessary for direct conversion of embryonic fibroblasts into neural crest cells
por: Motohashi, Tsutomu, et al.
Publicado: (2016)

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons
por: Hayashi, Yukari, et al.
Publicado: (2016)

Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking
por: Ojima, Kento, et al.
Publicado: (2021)

Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning
por: Shikanai, Mima, et al.
Publicado: (2023)

Purification of cardiomyocytes and neurons derived from human pluripotent stem cells by inhibition of de novo fatty acid synthesis
por: Tanosaki, Sho, et al.
Publicado: (2022)

Synthetic mRNA‐based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease‐induced pluripotent stem cells
por: Akiyama, Tomohiko, et al.
Publicado: (2020)

Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma
por: Shiihashi, Gen, et al.
Publicado: (2017)

Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells
por: Hirata, Tetsuya, et al.
Publicado: (2012)

A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells
por: Bektas, Meryem, et al.
Publicado: (2005)

Repression of Global Protein Synthesis by Eif1a-Like Genes That Are Expressed Specifically in the Two-Cell Embryos and the Transient Zscan4-Positive State of Embryonic Stem Cells
por: Hung, Sandy S. C., et al.
Publicado: (2013)

Ionotropic Glutamate Receptor AMPA 1 Is Associated with Ovulation Rate
por: Sugimoto, Mayumi, et al.
Publicado: (2010)

Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions
por: Saegusa, Shintaro, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dnbohl1plj4rtumqbe8h1jrr0h