Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice

Autoantigen-specific immunological tolerance represents a central objective for prevention of type 1 diabetes (T1D). Previous studies demonstrated mucosal antigen administration results in expansion of Foxp3(+) and LAP(+) regulatory T cells (Tregs), suggesting oral delivery of self-antigens might re...

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Detalles Bibliográficos
Autores principales: Posgai, Amanda L., Wasserfall, Clive H., Kwon, Kwang-Chul, Daniell, Henry, Schatz, Desmond A., Atkinson, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304332/
https://www.ncbi.nlm.nih.gov/pubmed/28205558
http://dx.doi.org/10.1038/srep42372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304332/
https://www.ncbi.nlm.nih.gov/pubmed/28205558
http://dx.doi.org/10.1038/srep42372

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