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How can functional annotations be derived from profiles of phenotypic annotations?

BACKGROUND: Loss-of-function phenotypes are widely used to infer gene function using the principle that similar phenotypes are indicative of similar functions. However, converting phenotypic to functional annotations requires careful interpretation of phenotypic descriptions and assessment of phenot...

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Detalles Bibliográficos
Autores principales: Serrano-Solano, Beatriz, Díaz Ramos, Antonio, Hériché, Jean-Karim, Ranea, Juan A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304448/
https://www.ncbi.nlm.nih.gov/pubmed/28183267
http://dx.doi.org/10.1186/s12859-017-1503-5