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Neuropathology of SUDEP: Role of inflammation, blood-brain barrier impairment, and hypoxia

OBJECTIVE: To seek a neuropathologic signature of sudden unexpected death in epilepsy (SUDEP) in a postmortem cohort by use of immunohistochemistry for specific markers of inflammation, gliosis, acute neuronal injury due to hypoxia, and blood-brain barrier (BBB) disruption, enabling the generation o...

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Detalles Bibliográficos
Autores principales: Michalak, Zuzanna, Obari, Dima, Ellis, Matthew, Thom, Maria, Sisodiya, Sanjay M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304466/
https://www.ncbi.nlm.nih.gov/pubmed/28087824
http://dx.doi.org/10.1212/WNL.0000000000003584