Cargando…

Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway

PURPOSE: In recent years, understanding of the role of asparaginyl endopeptidase (AEP) in tumorigenesis has steadily increased. In this study, we investigated whether AEP expression correlates with sensitivity to chemotherapeutic drugs in gastric cancer and explored the mechanism. PATIENTS AND METHO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Yuehong, Li, Qian, Li, Hong, Wang, Yan, Wang, Hongshan, Chen, Weidong, Zhang, Shangmin, Cao, Jian, Liu, Tianshu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304996/ https://www.ncbi.nlm.nih.gov/pubmed/28223821 http://dx.doi.org/10.2147/OTT.S125579

Ejemplares similares

Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition
por: Cui, Yuehong, et al.
Publicado: (2016)

Asparaginyl endopeptidases: enzymology, applications and limitations
por: Tang, T. M. Simon, et al.
Publicado: (2021)

Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer
por: Xu, Xiaojing, et al.
Publicado: (2023)

Plant asparaginyl endopeptidases and their structural determinants of function
por: Nonis, Samuel G., et al.
Publicado: (2021)

Use of an asparaginyl endopeptidase for chemo-enzymatic peptide and protein labeling
por: Tang, T. M. Simon, et al.
Publicado: (2020)

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases
por: Jackson, M. A., et al.
Publicado: (2018)

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
por: Harris, Karen S., et al.
Publicado: (2015)

Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer’s disease
por: Wang, Shan-Shan, et al.
Publicado: (2021)

Site-Specific Protein Modifications by an Engineered Asparaginyl Endopeptidase from Viola canadensis
por: Chen, Yu, et al.
Publicado: (2021)

Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis
por: Xu, Cheng, et al.
Publicado: (2017)

The Asparaginyl Endopeptidase Legumain: An Emerging Therapeutic Target and Potential Biomarker for Alzheimer’s Disease
por: Song, Mingke
Publicado: (2022)

Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury
por: Hu, Wen, et al.
Publicado: (2018)

Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1
por: Lei, Chuntao, et al.
Publicado: (2022)

The Asparaginyl Endopeptidase Legumain Is Essential for Functional Recovery after Spinal Cord Injury in Adult Zebrafish
por: Ma, Liping, et al.
Publicado: (2014)

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta
por: Poon, Simon, et al.
Publicado: (2018)

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors
por: Du, Junqiao, et al.
Publicado: (2020)

Site-Specific Protein Labeling and Generation of Defined Ubiquitin-Protein Conjugates Using an Asparaginyl Endopeptidase
por: Fottner, Maximilian, et al.
Publicado: (2022)

Suppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors
por: Yao, Peng, et al.
Publicado: (2017)

One-step asparaginyl endopeptidase (OaAEP1)-based protein immobilization for single-molecule force spectroscopy
por: Ding, Xuan, et al.
Publicado: (2022)

Hololectin Interdomain Linker Determines Asparaginyl Endopeptidase-Mediated Maturation of Antifungal Hevein-Like Peptides in Oats
por: Loo, Shining, et al.
Publicado: (2022)

Pharmacological Inhibition of the Asparaginyl Endopeptidase (AEP) in an Alzheimer’s Disease Model Improves the Survival and Efficacy of Transplanted Neural Stem Cells
por: Cheng, Qing, et al.
Publicado: (2023)

IQGAP3 Promotes EGFR-ERK Signaling and the Growth and Metastasis of Lung Cancer Cells
por: Yang, Ying, et al.
Publicado: (2014)

Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids
por: Dutta, Anindita, et al.
Publicado: (2016)

Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation
por: Freeley, Simon, et al.
Publicado: (2018)

Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer’s disease-related pathologies in a senescence-accelerated mouse model
por: Wang, Ju, et al.
Publicado: (2021)

IQGAP1 and IQGAP2 are Reciprocally Altered in Hepatocellular Carcinoma
por: White, Colin D, et al.
Publicado: (2010)

The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers
por: Song, Fei, et al.
Publicado: (2023)

Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras
por: Morgan, Chase J., et al.
Publicado: (2019)

The human G1m1 allotype associates with CD4+ T-cell responsiveness to a highly conserved IgG1 constant region peptide and confers an asparaginyl endopeptidase cleavage site
por: Stickler, M M, et al.
Publicado: (2011)

Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3
por: Jinawath, Natini, et al.
Publicado: (2020)

Primary resistance to EGFR inhibition in glioblastoma is mediated by a TNF-JNK-Axl-ERK signaling axis
por: Guo, Gao, et al.
Publicado: (2017)

Reduced IQGAP2 Promotes Bladder Cancer through Regulation of MAPK/ERK Pathway and Cytokines
por: Song, Fei, et al.
Publicado: (2022)

Plastin 1 drives metastasis of colorectal cancer through the IQGAP1/Rac1/ERK pathway
por: Zhang, Tongtong, et al.
Publicado: (2020)

ADAM 17 endopeptidase
Publicado: (2009)

Arterivirus Serine Endopeptidase
por: Snijder, Eric J., et al.
Publicado: (2013)

The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients
por: Furue, Kazuhisa, et al.
Publicado: (2020)

Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins
por: Leissing, Thomas M., et al.
Publicado: (2022)

A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1
por: Vetterkind, Susanne, et al.
Publicado: (2017)

Engineering protein theranostics using bio-orthogonal asparaginyl peptide ligases
por: Wang, Zhen, et al.
Publicado: (2021)

Role of IQGAP1 in Carcinogenesis
por: Wei, Tao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_66afagf5ehjvlnug2adnh0vu4a