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Th40 cells (CD4(+)CD40(+) Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells
CD40-CD154 interaction is critically involved in autoimmune diseases, and CD4 T cells play a dominant role in the Experimental Autoimmune Encephalomyelitis (EAE) model of Multiple Sclerosis (MS). CD4 T cells expressing CD40 (Th40) are pathogenic in type I diabetes but have not been evaluated in EAE....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305068/ https://www.ncbi.nlm.nih.gov/pubmed/28192476 http://dx.doi.org/10.1371/journal.pone.0172037 |