Increased spontaneous recombination in RNase H2-deficient cells arises from multiple contiguous rNMPs and not from single rNMP residues incorporated by DNA polymerase epsilon

Ribonucleotides can become embedded in DNA from insertion by DNA polymerases, failure to remove Okazaki fragment primers, R-loops that can prime replication, and RNA/cDNA-mediated recombination. RNA:DNA hybrids are removed by RNase H enzymes. Single rNMPs in DNA are removed by RNase H2 and if they r...

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Detalles Bibliográficos
Autores principales: Epshtein, Anastasiya, Potenski, Catherine J., Klein, Hannah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305187/
https://www.ncbi.nlm.nih.gov/pubmed/28203566
http://dx.doi.org/10.15698/mic2016.06.506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305187/
https://www.ncbi.nlm.nih.gov/pubmed/28203566
http://dx.doi.org/10.15698/mic2016.06.506

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