Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer

Prostate cancer is driven by androgen stimulation of the androgen receptor (AR). The next-generation AR antagonist, enzalutamide, prolongs survival, but resistance and lethal disease eventually prevail. Emerging data suggest that the glucocorticoid receptor (GR) is upregulated in this context, stimu...

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Detalles Bibliográficos
Autores principales: Li, Jianneng, Alyamani, Mohammad, Zhang, Ao, Chang, Kai-Hsiung, Berk, Michael, Li, Zhenfei, Zhu, Ziqi, Petro, Marianne, Magi-Galluzzi, Cristina, Taplin, Mary-Ellen, Garcia, Jorge A, Courtney, Kevin, Klein, Eric A, Sharifi, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305204/
https://www.ncbi.nlm.nih.gov/pubmed/28191869
http://dx.doi.org/10.7554/eLife.20183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305204/
https://www.ncbi.nlm.nih.gov/pubmed/28191869
http://dx.doi.org/10.7554/eLife.20183

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