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Transcription leads to pervasive replisome instability in bacteria

The canonical model of DNA replication describes a highly-processive and largely continuous process by which the genome is duplicated. This continuous model is based upon in vitro reconstitution and in vivo ensemble experiments. Here, we characterize the replisome-complex stoichiometry and dynamics...

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Detalles Bibliográficos
Autores principales: Mangiameli, Sarah M, Merrikh, Christopher N, Wiggins, Paul A, Merrikh, Houra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305214/
https://www.ncbi.nlm.nih.gov/pubmed/28092263
http://dx.doi.org/10.7554/eLife.19848