Cargando…

Differential inhibitory action of apixaban on platelet and fibrin components of forming thrombi: Studies with circulating blood and in a platelet-based model of thrombin generation

INTRODUCTION: Mechanisms of action of direct oral anticoagulants (DOAC) suggest a potential therapeutic use in the prevention of thrombotic complications in arterial territories. However, effects of DOACs on platelet activation and aggregation have not been explored in detail. We have investigated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pujadas-Mestres, Lluis, Lopez-Vilchez, Irene, Arellano-Rodrigo, Eduardo, Reverter, Joan Carles, Lopez-Farre, Antonio, Diaz-Ricart, Maribel, Badimon, Juan Jose, Escolar, Gines
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305231/ https://www.ncbi.nlm.nih.gov/pubmed/28192448 http://dx.doi.org/10.1371/journal.pone.0171486

Ejemplares similares

Reversal of Apixaban Induced Alterations in Hemostasis by Different Coagulation Factor Concentrates: Significance of Studies In Vitro with Circulating Human Blood
por: Escolar, Gines, et al.
Publicado: (2013)

Impact of different pathogen reduction technologies on the biochemistry, function, and clinical effectiveness of platelet concentrates: An updated view during a pandemic
por: Escolar, Gines, et al.
Publicado: (2021)

Contribution of neutrophil elastase to the lysis of obliterative thrombi in the context of their platelet and fibrin content
por: Rábai, Gyöngyi, et al.
Publicado: (2010)

Fibrinolysis in Platelet Thrombi
por: Kanji, Rahim, et al.
Publicado: (2021)

Spatial Distribution of Factor Xa, Thrombin, and Fibrin(ogen) on Thrombi at Venous Shear
por: Berny, Michelle A., et al.
Publicado: (2010)

Platelet-released extracellular vesicles: the effects of thrombin activation
por: Suades, Rosa, et al.
Publicado: (2022)

Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi
por: Höök, Peter, et al.
Publicado: (2017)

Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series
por: Rapkiewicz, Amy V., et al.
Publicado: (2020)

Thrombin induced platelet-fibrin clot strength in relation to platelet volume indices and inflammatory markers in patients with coronary artery disease
por: Lv, Hai-Chen, et al.
Publicado: (2017)

Study of antibacterial and antifungal efficacy of platelet-rich fibrin and platelet-rich fibrin matrix
por: Nagaraja, Shruthi, et al.
Publicado: (2019)

Platelet-rich fibrin and titanium-prepared platelet-rich fibrin in endoperio lesion management
por: Choudhary, Balram, et al.
Publicado: (2023)

STUDIES ON THROMBIN-INDUCED PLATELET AGGLUTINATION
por: Shermer, Richard W., et al.
Publicado: (1961)

Platelet thrombin receptor antagonism and atherothrombosis
por: Angiolillo, Dominick J., et al.
Publicado: (2010)

Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats
por: Lo, Sara T., et al.
Publicado: (2023)

Effects of different shear rates on the attachment and detachment of platelet thrombi
por: SHI, XIAOFENG, et al.
Publicado: (2016)

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor
Publicado: (1992)

Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome
por: Undas, Anetta, et al.
Publicado: (2008)

Series with complete resolution of left atrial appendage thrombi with apixaban in elderly patients
por: Lee, Sang Hoon, et al.
Publicado: (2016)

Comparative analysis of platelet-rich fibrin, platelet-rich fibrin with hydroxyapatite and platelet-rich fibrin with alendronate in bone regeneration: A cone-beam computed tomography analysis
por: Tiwari, Urvashi Ojha, et al.
Publicado: (2020)

Transport and storage of serotonin by thrombin-treated platelets
Publicado: (1975)

Metabolic Plasticity in Resting and Thrombin Activated Platelets
por: Ravi, Saranya, et al.
Publicado: (2015)

Fatal dysfunction and disintegration of thrombin-stimulated platelets
por: Kim, Oleg V., et al.
Publicado: (2019)

Impact of Edoxaban on Thrombin-Dependent Platelet Aggregation
por: Sokol, Juraj, et al.
Publicado: (2020)

Thrombin generation abnormalities in Quebec platelet disorder
por: Brunet, Justin G., et al.
Publicado: (2020)

Architectural and Ultrastructural Variations of Human Leukocyte-Rich Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin
por: Jasmine, Sharmila, et al.
Publicado: (2021)

Abnormal Whole Blood Thrombi in Humans with Inherited Platelet Receptor Defects
por: Castellino, Francis J., et al.
Publicado: (2012)

Comparison of Effects of Anti-thrombin Aptamers HD1 and HD22 on Aggregation of Human Platelets, Thrombin Generation, Fibrin Formation, and Thrombus Formation Under Flow Conditions
por: Derszniak, Katarzyna, et al.
Publicado: (2019)

Platelet Rich Fibrin in Periodontal Regeneration
por: Arunachalam, Muthukumaraswamy, et al.
Publicado: (2016)

Efficacy of Platelet Rich Fibrin in Myringoplasty
por: Riaz, Nida, et al.
Publicado: (2021)

A Novel Platelet Concentrate: Titanium-Prepared Platelet-Rich Fibrin
por: Tunalı, Mustafa, et al.
Publicado: (2014)

Platelet-Rich Plasma and Platelet-Rich Fibrin as a Regenerative Tool
por: Inbarajan, Athiban, et al.
Publicado: (2021)

Effects of leukocyte–platelet-rich fibrin and advanced platelet-rich fibrin on the viability and migration of human gingival fibroblasts
por: Esfahrood, Zeinab Rezaei, et al.
Publicado: (2020)

Antibacterial and Antifungal Efficacy of Platelet-Rich Fibrin and Platelet-Rich Fibrin Matrix against Root Canal Microflora
por: Singh, Pinky, et al.
Publicado: (2021)

The Effectiveness of Advanced Platelet-Rich Fibrin in comparison with Leukocyte-Platelet-Rich Fibrin on Outcome after Dentoalveolar Surgery
por: Makki, Alaa Z., et al.
Publicado: (2021)

Comparative evaluation of radiopacity and cytotoxicity of platelet-rich fibrin, platelet-rich fibrin + 50wt% nano-hydroxyapatite, platelet-rich fibrin + 50wt% dentin chips: An in vitro study
por: Mahendran, Kavitha, et al.
Publicado: (2019)

Automated Thrombin Generation Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements
por: Meihandoest, Tamana, et al.
Publicado: (2021)

Platelet–Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi
por: Pir, Ghulam Jeelani, et al.
Publicado: (2022)

Comparative evaluation of platelet-rich fibrin, platelet-rich fibrin + 50 wt% nanohydroxyapatite, platelet-rich fibrin + 50 wt% dentin chips on odontoblastic differentiation - An in vitro study-part 2
por: Girija, Kottuppallil, et al.
Publicado: (2020)

The human complement system in thrombin-mediated platelet function
Publicado: (1978)

Redistribution of alpha-granules and their contents in thrombin- stimulated platelets
Publicado: (1984)

Cannot write session to /tmp/vufind_sessions/sess_q2mo58j3n4hdmceh42v4gsgb2h