Lesion remyelinating activity of GSK239512 versus placebo in patients with relapsing-remitting multiple sclerosis: a randomised, single-blind, phase II study

Histamine H(3) receptor blockade may enhance lesion remyelination in multiple sclerosis (MS). The efficacy (using a magnetic resonance imaging marker of myelination, magnetisation transfer ratio [MTR]), safety and pharmacokinetics of GSK239512, a potent and brain penetrant H(3) receptor antagonist/i...

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Detalles Bibliográficos
Autores principales: Schwartzbach, Caryl J., Grove, Richard A., Brown, Robert, Tompson, Debra, Then Bergh, Florian, Arnold, Douglas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306088/
https://www.ncbi.nlm.nih.gov/pubmed/27888416
http://dx.doi.org/10.1007/s00415-016-8341-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306088/
https://www.ncbi.nlm.nih.gov/pubmed/27888416
http://dx.doi.org/10.1007/s00415-016-8341-7

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